From New York City - George Washington Bridge to I-80 West. In PA, exit from I-80 (the Keystone Shortway) at Exit #161 (Bellefonte) and follow Route 220 South to State College exit #74.
From Philadelphia - Take the Northeast Extension of the Pennsylvania Turnpike to I-80. Take Exit #161 (Bellefonte) and follow Route 220 South to State College exit #74. -OR- Take Philadelphia Schuylkill Expressway to the Pennsylvania Turnpike, leave the Turnpike at Exit #247 (Harrisburg East), and follow I-283 to I-83 and proceed North on I-83 to the I-81 interchange. Then follow I-81 West to Route 322, 22 West Exit. Proceed West on Route 322 through Lewistown to State College Exit #74.
From Pittsburgh - Follow Route 22 East to Duncansville, I-99/Route 220 North to Route 322 East to Mt Nittany Expressway/State College Exit #73.-OR- Follow Route 22 East beyond Duncansville to Water Street, Route 45 East to Pine Grove Mills and Route 26 North to State College.
From Washington D.C. - Take Route 270 to Frederick then Route 70 to Breezewood - PA turnpike (Exit #161) - and go one Exit West to Bedford (Exit #146); Take I-99 North to Rt. 220 to Route 322 East to State College Exit #74 -OR- Take I-95 or the Baltimore-Washington Parkway to Baltimore, West loop I-695 to I-83 North. Continue on I-83 North to the I-81 interchange. Then follow I-81 West to Route 322, 22 Exit. Proceed West on Route 322 to Lewistown and State College.
From the West - Take I-80 to Exit #123 (Woodland) just East of Clearfield, then Route 322 East to State College. -OR- One may also Exit I-80 at Exit #161 (Bellefonte) and follow Route 220 South to State College Exit #74.

